I began research as an undergraduate at Harvard College, initially studying the effects of vitamin A deficiency on the photoreceptors in the eye that capture the light and initiate vision. After receiving my PhD and starting my own laboratory, I became fascinated with the other four classes of cells/neurons found in the retina, which begin the analysis of visual information: two being in the outer retina and two in the inner retina. We mapped out the synaptic interactions among the neurons, recorded from them, and began to put together the neural circuitries that underlie the visual messages that are sent to other parts of the brain.
I wrote
Understanding the Brain: From Cells to Behavior to Cognition
One of the world’s best neuroscientists, who won the Nobel Prize in 2000, engagingly describes neurological and cognitive diseases/conditions and how they can be debilitating but, in some cases, can lead to extraordinary mental abilities in memory, visual arts, etc.
It came out the same year as my book, and it adds to and complements it. I found the descriptions of brain disorders compelling and the history of psychiatry woven into the chapters fascinating. The relationship between certain cognitive disorders and highly creative people is discussed, and an intriguing reason for this is proposed.
Neurological and psychiatric disorders have long been regarded as fundamentally different, depending on whether they appear to affect the brain or the mind. In reality, the brain and the mind are inseparable. Both types of disorder can affect every aspect of brain function: from perception, action, memory and emotion to empathy, social interaction, attention and consciousness.
It is easy to view brain disorders as simply tragic or frightening. However, studying where these functions go wrong provides a window on the workings of the healthy brain, and makes it more likely that scientists and clinicians will be able to develop effective…
Although this book has been around for a very long time, I only encountered it earlier this year.
It is a scientific fiction novel based on a supposed treatment given to a mentally handicapped young man (Charlie) that gave him great intelligence. This treatment had been tried earlier on mice (one being Algernon), enabling them to do cognitive tasks impossible for ordinary mice. The basis for much of the book was that the treatment was not permanent, and first, Algernon and then Charlie deteriorated back to where they were cognitively before the treatment.
The book beautifully describes what it was like (in Charlie’s own words) to be cognitively disabled before the treatment and how he was treated by people; then, when the treatment was effective, and finally, as he was deteriorating, which he recognized was happening. Although fictional, the descriptions of the cognitive changes in Charlie are compelling.
James Malloy is a ferry captain--or used to be, until he was unceremoniously fired and replaced by a "girl" named Courtney Farris. Now, instead of piloting Brenton Island’s daily lifeline to the glitzy docks of Newport, Rhode Island, James spends his days beached, bitter, and bored.
One of Oliver Sack’s delightful books containing stories of individuals with various neurological disorders. I read the first one, The Man Who Mistook His Wife for a Hat, back in the 1980s when it first came out and was hooked, now having read almost all of them.
The one I am recommending is, I believe, more relevant to an understanding of brain mechanisms. One criticism I have had of Sack’s books is that there is little in the way of neurobiological explanations for the conditions described. In my book, most chapters begin with a Sack-like story about a specific neurological condition that is then explained, as far as possible, neurobiologically in the chapter.
As with his previous bestseller, The Man Who Mistook His Wife for a Hat, in An Anthropologist on Mars Oliver Sacks uses case studies to illustrate the myriad ways in which neurological conditions can affect our sense of self, our experience of the world, and how we relate to those around us.
Writing with his trademark blend of scientific rigour and human compassion, he describes patients such as the colour-blind painter or the surgeon with compulsive tics that disappear in the operating theatre; patients for whom disorientation and alienation - but also adaptation - are inescapable facts of life.
I very much enjoy reading biographies and autobiographies about scientists. My favorite is Cajal’s autobiography.
Cajal is considered by many to be the Father of Neuroscience. He grew up in Spain, where he lived his entire life. He loved to draw and wanted to become an artist, but his father discouraged this, so he went to medical school. He used his artistic skills to great advantage when he began to study the brain and its cells. His drawings are meticulous, exceptionally accurate, and have never been surpassed.
Virtually every book on neuroscience includes some of his drawings. This book recounts not only his scientific career but also other of his fascinations. He loved chess and played it with individuals all over the world, but he gave it up because it was taking up too much of his time.
Santiago Ramón y Cajal (1852-1934) made prolific and lasting contributions to understanding "the life of the infinitely small."
Santiago Ramón y Cajal (1852-1934) made prolific and lasting contributions to understanding "the life of the infinitely small." Widely thought of as the founder of neuroscience, Cajal made remarkable explorations into the organization and function of the nervous system. His work is still referred to more than that of any other scientist in the field.W. Maxwell Cowan's foreword to this edition conveys the excitement and energy of Cajal's life and endeavors, the liveliness and flamboyance of his engagements with the microscope. Cowan…
Nine Stories Told Completely in Dialogue is a unique collection of narratives, each unfolding entirely through conversations between its characters. The book opens with "God on a Budget," a tale of a man's surreal nighttime visitation that offers a blend of the mundane and the mystical. In "Doctor in the…
This fascinating book is essentially the story of prefrontal lobotomies and the surgery that was developed to carry out the procedure. Although it did help certain violent patients, it had serious side effects not recognized initially and was used inappropriately on too many patients (including President Kennedy’s sister).
The book recounts the history of why the procedure was developed and many of the scientists and surgeons involved. It provides a perfect case study of the caution needed when a new, thought to be miraculous, treatment for any disease is first tried.
Artificial intelligence is very much in the news these days, but what is natural intelligence, and how and where is it generated? In the brain, of course! This book was written for the reader curious about how the brain does this and what we now know about the brain. It requires scientific knowledge only at the high school level, and I have used it to teach Harvard Freshmen.
As the title indicates, it first covers brain cells, brain development, brain signaling, drugs and brains, and how we sense the world; then simple and more complex behaviors; and lastly, cognition including perception, brain plasticity, language, memory and learning, emotions and rationality, and sleep and consciousness.
This memoir chronicles the lives of three generations of women with a passion for reading, writing, and travel. The story begins in 1992 in an unfinished attic in Brooklyn as the author reads a notebook written by her grandmother nearly 100 years earlier. This sets her on a 30-year search…
Four years old and homeless, William Walters boarded one of the last American Orphan Trains in 1930 and embarked on an astonishing quest through nine decades of U.S. and world history.
For 75 years, the Orphan Trains had transported 250,000 children from the streets and orphanages of the East Coast…
